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KMID : 1216720100020010032
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Korean Journal of Gynecologic Endocrinology
2010 Volume.2 No. 1 p.32 ~ p.38
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Serum Vascular Endothelial Growth Factor Concentrations in Patients with Uterine Leiomyoma
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Jee Byung-Chul
Suh Chang-Suk
Kim Seok-Hyun
Kim Jung-Gu
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Abstract
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Objectives: To investigate whether serum levels of vascular endothelial growth factor (VEGF) correlate with leiomyoma-related symptoms and weights of leiomyoma-bearing uteri in patients with uterine leiomyoma. Methods: Twenty-four women included who were scheduled to undergo hysterectomy due to uterine leiomyoma in University-based Hospital. Serum VEGF-A levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer\’s instruction. Weights of leiomyoma-bearing uteri were recorded postoperatively. Results: There were no significant differences in VEGF-A levels between the patients with or without menorrhagia (219.3±193.8 vs. 306.9±304.1 pg/ml), and between the patients with or without dysmenorrhea (111.8±39.1 vs. 268.0±243.3 pg/ml). Serum VEGF-A levels did not correlate with weights of leiomyoma-bearing uteri in patients with uterine leiomyoma (r=-0.091, P=0.671). Conclusion: Serum VEGF levels may be not correlated with the leiomyoma-related symptoms, or weights of leiomyoma-bearing uteri. Serum VEGF-A levels may not be a clinical marker of uterine leiomyoma.
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KEYWORD
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Vascular endothelial growth factor, Uterine leiomyoma, Uterine weights
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